Blisters: Causes, Prevention and Treatment

Blisters, though often small in size, can cause significant discomfort and inconvenience.

Understanding the symptoms, causes, and treatment options for blisters is crucial for effective management and prevention.

In this article, we will delve into the diverse array of blister types, explore the common triggers behind their formation, and discuss practical approaches to both alleviate immediate discomfort and foster healing.

Blisters can be filled with blood (as above), fluid, or pus.
Blisters can be filled with blood (as above), fluid, or pus.

What is a Blister?

A blister is a fluid-filled sac that forms underneath the first layer of skin.

Most often the fluid is clear. This fluid is called serum, and leaks into the area from surrounding tissue. It is similar to plasma, which is blood without the red blood cells. It is sterile while the blister remains intact.

Occasionally, especially if caused by an injury, a blister can fill with blood – this is called a blood blister. If it becomes infected, the fluid inside the blister will be milky-white or yellow pus.

Blisters can contain a mixture of the above fluids, depending on how they were formed and how they progress.

If a blister is the result of a viral infection or bacterial infection, it will contain viral or bacterial particles. These can cause further infection in others who come into contact with it.

Sunburn can cause bad blistering of the skin.
Sunburn can cause bad blistering of the skin.

What Causes Blisters?


The most common cause of blisters is pressure or friction on the skin. Most of us have experienced this with new shoes, for example, or when using gardening tools.

The skeletal parts of the foot or hand move out of sync with the skin and tissue, and when this happens repeatedly it can cause a tear underneath the skin. This tear then fills with fluid.

Increased skin temperature and moisture can increase the likelihood of developing friction blisters.


Occasionally, injuries can cause blisters to form. These can include:

  • Sunburn
  • Frostbite
  • Chilblains
  • Insect bites or stings
  • Scalds or burns
  • Pressure ulcers (bedsores)
  • Contact dermatitis


Blisters can also be cause by certain infections or diseases including:

  • Chickenpox and Shingles
  • Hand, Foot, and Mouth Disease
  • Impetigo (School Sores)
  • Cellulitis
  • The Herpes Virus, causing Cold Sores or Genital Herpes
  • Autoimmune Diseases, such as Pemphigus
  • Inherited Diseases, such as Epidermolysis Bullosa

Blisters that are caused by infection diseases can spread that disease very easily.
Blisters that are caused by infection diseases can spread that disease very easily.

Are Blisters Dangerous?

Friction blisters can become more than a minor nuisance. For hikers, athletes and military personnel, blisters can be a regular occurrence that have a significant impact on their ability to compete and/or do their jobs.

In fact, friction blisters can be disabling. The pain caused by blisters, combined with their location, often mean that a person is unable to comfortably walk, let alone anything more strenuous.

If a friction blister were to become infected, it could lead to complications such as cellulitis, sepsis, or toxic shock syndrome.

Blisters that are not caused by friction indicate an underlying health condition. If you are not already managing these under the care of your doctor, it is critical that you do so.

Viral and bacterial blisters pose a risk to others through contact, which can spread the disease.

Treating Blisters

Some blisters can be managed at home, others should be managed under the care of your doctor.

Interestingly, there has been little scientific research into blister treatment in the past 30 years, despite their prevalence and impact.

If the blister is small, it will likely dry out within a fortnight. It may heal better if you are able to leave it alone, as the skin covering will help prevent infection and scarring.

You can cover individual intact blisters with a loose bandage:

  • Cut a doughnut shape from a padded dressing and place it around the blister (so that the blister sits within the hole of the doughnut shape)
  • Cover the blister and dressing with a bandage

If the blister has burst:

  • Gently wash the affected area clean
  • If the skin on the top of the blister is still attached, carefully position it back in place – this helps it to heal faster
  • Cover with a band-aid or bandage
  • If the skin has torn away completely, cover with a special blister plaster (which you can get from your local pharmacy)

Puncturing a blister is often tempting, but can cause serious infection if they are not allowed to heal properly. Bursting blisters caused by diseases and injuries can spread the infection to other parts of the body, and even to other people.

If your blister is particularly large, painful, or irritating, you may decide to puncture it to relieve the pain and pressure, and to allow it it heal faster. These are the steps to follow:

  • Wash your hands and the blister
  • Use rubbing alcohol to sterilize a clean needle
  • Puncture the edge of the blister (not the middle) in multiple locations, and let the fluid drain out – make sure the roof of the blister remains intact
  • Wash the area again
  • Apply a compressive dressing to help the blister skin reattach to the underlying layers – a piece of dry gauze secured with a compressive elastic wrap is perfect
  • Repeat this process every 6-8 hours during the first 24 hours to relieve pain and the accumulation of further fluid
  • Watch carefully as it heals to ensure there are no signs of infection

If a blister is serious, or caused by a disease or infection, you will need to have it seen by a doctor for appropriate management. You may need antibiotics or other medication.

Blisters caused by illness or burns should be treated by a doctor.
Blisters caused by illness or burns should be treated by a doctor.

Preventing Blisters

Preventing blisters that are caused by friction can be done by:

  • Wearing moisture-wicking socks
  • Wearing gloves when using tools, e.g., during gardening or home renovations

There are some other common recommendations for preventing friction blisters. Unfortunately, these either haven’t been backed by any scientific studies, or the results indicate they have no effect or actually increase the risk of blister development:

  • Shoe fit
  • Covering friction-prone areas with micropore tape or band aids
  • Using anti-friction balm on the skin
  • Applying antiperspirants, talcum powder, or other drying powders
  • Using lubricating agents

Unfortunately, if blisters are caused by diseases, there isn’t anything you can do to prevent the blisters themselves. Your best course of action is to ensure you are up-to-date with your vaccinations and try to avoid catching the viruses or bacteria that cause the diseases.

Blisters linked to inherited and autoimmune diseases likely cannot be avoided, but you should consult with your doctor about appropriate management.

Blisters that are related to contact dermatitis can be avoided by avoiding contact with the irritant.

Take care to avoid injuries such as sunburn, frostbite, insect stings, and pressure ulcers that may also cause blisters.


Blisters are common, especially amongst those who are physically active.

While they are not life-threatening, they certainly can impact your ability to enjoy daily life.

Understanding correct blister care can help you to recover faster, avoid infection, and in turn avoid scarring.

More articles

First Aid for Concussion article headerFirst Aid for Concussion
Online Gaming Injuries article headerCommon Online Gaming Injuries
Common netball injuries article headerCommon Netball Injuries
Blood blister article headerHow to Treat Blood Blisters
Bird Scratches and Bites article headerFirst Aid for Bird Scratches and Bites
Blister article headerBlisters: Causes, Prevention and Treatment
Photokeratitis article headerEye Sunburn
Understanding and Managing Lip InjuriesManaging Lip Injuries
Jaw Injuries article headerTypes of Jaw Injuries
First Aid for Tongue InjuriesFirst Aid for Tongue Injuries

Recently published

Cold vs heat pack article headerCold Packs vs. Heat Packs
Cold packs article headerHow and When to Use a Cold Pack
Mould article headerHousehold Mould
First Aid for Concussion article headerFirst Aid for Concussion
Non-birth parent postpartum depression article headerPostpartum Depression In The Non-Birthing Parent
Summer Safety Tips article headerSummer Safety Tips for Your Eyes
Incorrect Mental Health Crisis Intervention article headerRisks of Incorrect Mental Health Crisis Intervention
Saline eye rinse article headerSterile Saline Tubes for Rinsing Eyes
Online Gaming Injuries article headerCommon Online Gaming Injuries
Common netball injuries article headerCommon Netball Injuries